Synergistic Effects of Disintegrants on Release of poorly Water soluble drug
نویسندگان
چکیده
منابع مشابه
Effects of Lipids on Absorption of Poorly Water-Soluble Drugs
Introduction Although the capability of ingested lipids to enhance the bioavailability of poorly water-soluble drugs has been experimentally observed and established 1 , the phenomenon is not well understood and is unpredictable. Commercially, lipids could offer valuable opportunities for enabling oral drug delivery, as approximately 4070% of all new drug candidates have been estimated to have ...
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Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...
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The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical and Life Sciences
سال: 2012
ISSN: 2305-0330
DOI: 10.3329/ijpls.v1i3.12979